Six & Twenty Distillery Claim this business

About

Six & Twenty is a working grain-to-glass distillery in the Village of West Greenville, set inside the Poe West building where the whole process runs under one roof. They mill, ferment, distill, and barrel-age on site, so the tasting room sits just steps from the still doing the work. Drinking the spirits where they are actually made is the draw. The space works as both a tasting bar and a cocktail bar. Order a flight to move across the lineup, let the bartenders build something from scratch, or sit in on one of the Saturday grain-to-glass tours that walk you from South Carolina grain to finished spirit. Bottles are for sale to take home, and small plates round out a longer stay. The core pours lean on SC-grown corn and wheat and hold steady year-round: Old Money wheat whiskey, the 5 Grain Bourbon, Carolina Cream, and Heirloom Rye vodka. Beyond those, special bottlings come out on a rotating basis, so what is pouring shifts through the year. The name traces back to Six and Twenty Creek and the old Upstate legend of Isaqueena, a story the staff will gladly tell in full. Regulars keep coming back for the Carolina Cream and the Old Money whiskey, and the tours earn steady credit for guides who make the craft genuinely interesting rather than a sales pitch. Figuring out which pour becomes your bottle, and catching the next limited release when it lands, is the kind of thing you sort out by asking.